EMANUEL S. HELLMAN, M.D.; DONALD P. TSCHUDY, M.D.
HELLMAN ES, TSCHUDY DP. "Restless Legs" Syndrome in Acute Intermittent Porphyria. Ann Intern Med. 1962;56:487-489. doi: 10.7326/0003-4819-56-3-487
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Published: Ann Intern Med. 1962;56(3):487-489.
A syndrome of unpleasant paresthesias, predominantly in the lower extremities, and the resultant voluntary, restless, twitching motions on the part of the sufferer to obtain relief, was probably first noted by Willis in 1685 (1). Attention was redirected to this sympton complex by Ekbom in 1944 and in his subsequent publications (2-4) where he applied the term "restless legs" to this syndrome. "Restless legs" developing in a patient with acute intermittent porphyria is presented and documented as yet another symptom in a disease of protean manifestations.
The patient was a 58-year-old white male former machinist. Hypertension, apparently labile
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