A. P. Shapiro, M.D. (Assoc.)
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Studies of hypotensive drugs in hypertensive patients are limited usually to evaluation of effects on basal blood pressures. It would seem important, however, to determine effects of drugs on pressor responses following noxious stimuli. In a previous study, hyper-reactivity to several psychologic and physical stimuli was demonstrated in a group of hypertensive patients. Although age, sex, and type of stimulus influenced intensity of pressor responses, the level of resting pressure did not. Moreover, normotensive subjects with family history of hypertension were hyper-reactors.
In the present study, the same techniques were used to evaluate the influence of reserpine and chlorothiazide on
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Shapiro AP. Pressor Responses to Noxious Stimuli in Hypertensive Patients: Effect of Reserpine and Chlorothiazide.. Ann Intern Med. 1962;56:671. doi: 10.7326/0003-4819-56-4-671_2
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Published: Ann Intern Med. 1962;56(4):671.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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