L. J. Marks, M.D. (Assoc.)
Marks LJ. Adrenocortical Function in Carcinoma of the Lung with and without Cushing's Syndrome.. Ann Intern Med. 1962;56:677. doi: 10.7326/0003-4819-56-4-677_1
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Published: Ann Intern Med. 1962;56(4):677.
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Adrenocortical function was studied in 44 patients with carcinoma of the lung by measuring their plasma 17-hydroxycorticosteroid response to adrenocorticotrophic hormone. Although Cushing's syndrome was not present in any of these subjects, 36% demonstrated an exaggerated plasma corticosteroid response to ACTH. The results of the adrenal function studies could be correlated better with the severity of the patient's clinical illness than with either a specific cell type of lung cancer or the alterations in the adrenals observed at autopsy. Bio-assays of the pituitary glands for ACTH were performed for seven cases who died from lung cancer, using hypophysectomized rats. The
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Adrenal Disorders, Endocrine and Metabolism, Hematology/Oncology, Lung Cancer, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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