FRED F. WHITCOMB JR., M.D.; CHARLES H. BROWN, M.D., F.A.C.P.
Pseudoxanthoma elasticum is a rare, heritable, systemic disease of connective tissues characterized by degeneration of elastic tissue and mainly affecting the skin, eyes, and blood vessels. It occurs more frequently in females than in males, and the disease probably is inherited as an autosomal recessive trait (1).
The clinical and histological changes in the skin in this condition were described by Balzer (2) in 1884. Darier (3), in 1896, defined the disease as a separate entity and suggested the name "pseudoxanthoma elasticum." The occurrence of angioid streaks in the retina was described by Grönblad (4) and Strandberg (5) in 1929,
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WHITCOMB FF, BROWN CH. Pseudoxanthoma Elasticum: Report of Twelve Cases: Massive Gastrointestinal Hemorrhage in One Patient. Ann Intern Med. 1962;56:834–842. doi: 10.7326/0003-4819-56-6-834
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Published: Ann Intern Med. 1962;56(6):834-842.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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