HAROLD J. SIMON, M.D., PH.D.; LOWELL A. RANTZ, M.D., F.A.C.P.
The synthesis of 6-aminopenicillanic acid (1) was followed very quickly by the appearance of several semi-synthetic penicillin homologues. The first of the semi-synthetic penicillins to become widely available after undergoing clinical trials was alpha-phenoxyethyl penicillin (Broxil) (2). The accumulated results of these studies demonstrated that phenoxyethyl penicillin possessed few advantages over alpha-phenoxymethyl penicillin (penicillin V). Its prime importance lay not so much in its antibacterial activities as in the demonstration that clinically active penicillins could now essentially be made to order. A pressing need existed for an agent with the major advantages of penicillin-G—a lack of toxicity, bactericidal efficiency, economy,
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SIMON HJ, RANTZ LA. The Newer Penicillins: I. Bacteriological and Clinical Pharmacological Investigations with Methicillin and Oxacillin. Ann Intern Med. 1962;57:335–343. doi: 10.7326/0003-4819-57-3-335
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Published: Ann Intern Med. 1962;57(3):335-343.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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