HORACE K. IVY, M.D.
IVY HK. Treatment of Breast Cancer with 5-Fluorouracil. Ann Intern Med. 1962;57:598-605. doi: 10.7326/0003-4819-57-4-598
Download citation file:
Published: Ann Intern Med. 1962;57(4):598-605.
The role of 5-fluorouracil in the chemotherapy of breast cancer has yet to be accurately defined. That it is useful and effective in some cases is beyond doubt, but its associated toxicity renders it a formidable agent to use.
For some years, metabolic differences between normal and neoplastic tissues have been sought with the hope that such differences could be exploited by chemotherapeutic agents. Both Rutman (1) and Heidelberger (2), with their co-workers, have observed that uracil may be preferentially utilized for synthesis of nucleic acid in certain neoplastic tissues. Consequently, several altered molecules of uracil were synthesized and their
Learn more about subscription options.
Register Now for a free account.
Hematology/Oncology, Breast Cancer.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only