MAURICE E. SHILS, M.D., SC.D.
SHILS ME. Renal Disease and the Metabolic Effects of Tetracycline. Ann Intern Med. 1963;58:389-408. doi: 10.7326/0003-4819-58-3-389
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Published: Ann Intern Med. 1963;58(3):389-408.
Reports of an azotemic effect of tetracyclines in certain patients have appeared sporadically since the initial observation of Bateman et al. on patients infused with oxytetracycline (1, 2) or chlortetracycline (2). The occasional clinical reports have been supported by studies with experimental animals, and indicate some association of unknown mechanism between tetracycline and an elevation in blood urea or non-protein nitrogen. Metabolic studies performed by Gabuzda et al. (3) and Faloon et al. (4-6) in patients reportedly without significant renal disease indicated that members of this group of antibiotics were capable of increasing urinary nitrogen excretion. This literature has been
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