N. M. Kaplan, M.D. (Associate)
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Metopirone (SU-4885) has been widely used as a test of pituitary ACTH reserve. Problems in the interpretation of the test remain, both in the definition of the normal response and in the meaning of the abnormal response.
A comparison was made between the urine and plasma levels of both 17-hydroxycorticoids (Porter-Silber chromogens) and 11-desoxycorticosteroids (11-DOCS) in healthy subjects and patients with and without pituitary disease. The response to Metopirone could be interpreted best by the changes in urine 11-DOCS excretion, the normal response being a rise of at least 7 mg/day above the control level. The use of P-S chromogen
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Kaplan NM. Tests of Pituitary ACTH Secretory Capacity.. Ann Intern Med. 1963;58:723. doi: 10.7326/0003-4819-58-4-723_1
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Published: Ann Intern Med. 1963;58(4):723.
Endocrine and Metabolism, Neurology, Pituitary Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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