J. T. Galambos, M.D. (Associate); J. R. McLaren, M.D.
Galambos JT, McLaren JR. A Diagnostic Test for "Gilbert's Disease.". Ann Intern Med. 1963;58:724. doi: 10.7326/0003-4819-58-4-724_2
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Published: Ann Intern Med. 1963;58(4):724.
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Intravenously administered 1-131 iodipamide (R.I.I.) is rapidly concentrated in the normal human liver. External monitoring of hepatic radioactivity for 15 minutes following intravenous injection of R.I.I, is a simple, reliable, and discriminating clinical liver function test. We have shown that patients as well as animals with liver damage have a depressed hepatic uptake of R.I.I. It has also been shown that 1-131 labeled rosebengal (RIRB) uptake is also depressed in the presence of liver disease. Gilbert's disease is diagnosed in patients who have recurrent indirect hyperbilirubinemia, usually under 5 mg/100 ml, by demonstrating normal liver morphology or biopsy, normal liver
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