L. G. Suhrland, M.D. (Associate); A. S. Weisberger, M.D., F.A.C.P.
Suhrland LG, Weisberger AS. Correlation of Erythropoietic Toxicity with the Serum Concentration of Chloramphenicol Metabolites in Patients with Renal or Hepatic Insufficiency.. Ann Intern Med. 1963;58:731. doi: 10.7326/0003-4819-58-4-731_1
Download citation file:
Published: Ann Intern Med. 1963;58(4):731.
This content is PDF only. Please click on the PDF icon to access.
The incidence of erythropoietic toxicity due to chloramphenicol was determined in patients with renal or hepatic insufficiency and correlated with alterations in the serum concentration of chloramphenicol metabolites. Erythropoietic depression was determined on the basis of changes in serum iron, delayed appearance of Fe59 in circulating erythrocytes, and by standard hematologic examinations of peripheral blood and bone marrow.
Chloramphenicol was administered orally, 2 g daily, to 16 patients with hepatic insufficiency and to 20 patients with renal disease in chronic uremia. The incidence of erythropoietic depression was determined in these patients and compared with that observed in 15 patients with
Learn more about subscription options.
Register Now for a free account.
Emergency Medicine, Gastroenterology/Hepatology, Nephrology, Liver Disease.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only