A. Haut, M.D. (Associate); G. E. Cartwright, M.D. (Associate); M. M. Wintrobe, M.D., F.A.C.P.
Haut A, Cartwright GE, Wintrobe MM. Studies on the Osmotic Resistance of Incubated Leptocytes.. Ann Intern Med. 1963;58:732-733. doi: 10.7326/0003-4819-58-4-732_3
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Published: Ann Intern Med. 1963;58(4):732-733.
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Erythrocytes from patients with thalassemia minor, iron deficiency anemia, liver disease associated with the target cells and an example of elliptocytosis were studied. These red cells are known to generally have a greater than normal osmotic resistance when studied in the fresh condition. We have found them to have an even greater osmotic resistance after their incubation in their own serum, under aseptic conditions for 24 hours, than before incubation. The increase in osmotic resistance was the opposite of the well-known change noted for normal cells under the same conditions. By virtue of this fact, the difference between the osmotic
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