R. G. Page, M.D. (Associate)
Page RG. Hydroxyprogesterone Caproate Enhancement of Diuretic Action in Man.. Ann Intern Med. 1963;58:744. doi: 10.7326/0003-4819-58-4-744_1
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Published: Ann Intern Med. 1963;58(4):744.
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Progesterone has been shown to have a natruretic effect due to its ability to antagonize aldosterone. We have noted an enhancement of the effectiveness of diuretics following the use of spironolactone, also an aldosterone antagonist, in patients with edema secondary to congestive heart failure. It seemed to us that progesterone might also increase the natruresis that follows the administration of diuretics in this group of patients.
Patients with congestive heart failure and edema were admitted to the research floors of The University of Chicago Hospitals and Clinics and maintained on constant diets. Daily weight, urinary volume, urinary sodium, potassium, and
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