VICTOR HERBERT, M.D.; RALPH ZALUSKY, M.D.; CHARLES S. DAVIDSON, M.D., F.A.C.P.
HERBERT V., ZALUSKY R., DAVIDSON C.; Correlation of Folate Deficiency with Alcoholism and Associated Macrocytosis, Anemia, and Liver Disease. Ann Intern Med. 1963;58:977-988. doi: 10.7326/0003-4819-58-6-977
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Published: Ann Intern Med. 1963;58(6):977-988.
Macrocytosis has been observed frequently in association with cirrhosis since 1884 (1). The concomitant presence of macrocytosis, anemia, and cirrhosis, usually in association with alcoholism, sometimes with a macronormoblastic or even a megaloblastic bone marrow, has been frequently noted in the medical literature (2-10).
In 1938, noting no correlation between macrocytosis and severity of liver damage, Bianco and Jolliffe (2) concluded: "In view of these findings we are inclined to regard the macrocytosis of the alcohol addict not as a manifestation of inability on the part of the liver to store a hematopoietic principle, but as an extrinsic deficiency of
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Gastroenterology/Hepatology, Hematology/Oncology, Tobacco, Alcohol, and Other Substance Abuse, Red Cell Disorders, Liver Disease.
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