Sigmundur Gudbjarnason, M.D.; Richard J. Bing, M.D., F.A.C.P.; Chiyo Chiba, M.D.; Christian DeSchryver, M.D.; Jiro Yamanaka, M.D.
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Myocardial infarction was produced in dogs by ligation of branches of the coronary arteries. The rate of incorporation of a radioactive amino acid, glycine-2-C14, into heart muscle protein was studied over a period of six weeks. Three samples were analyzed from each left ventricle close to the infarcted area: normal tissue, the infarcted area, and borderline tissue.
The infarcted tissue showed a rapid diminution in protein synthesis after infarction, but already on the third day, the incorporation into the infarcted tissue rose above the normal and reached a maximum after 4 days. This reflects the early destruction and the following
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Gudbjarnason S, Bing RJ, Chiba C, DeSchryver C, Yamanaka J. The Reaction of the Heart to Myocardial Infarction.. Ann Intern Med. 1964;60:320-321. doi: 10.7326/0003-4819-60-2-320_3
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Published: Ann Intern Med. 1964;60(2_Part_1):320-321.
Acute Coronary Syndromes, Cardiology, Coronary Heart Disease, Emergency Medicine.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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