Boy Frame, M.D., F.A.C.P.; R. J. Hartstock, M.D.; H. S. Ballard, M.D.
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The parathyroids, pancreatic islets, adrenals, and pituitary are the glands most frequently involved in the syndrome of multiple endocrine adenomatosis (MEA). In more than 50% of the reported cases peptic ulcer has been observed.
In a Negro family extending over five generations, 13 of 25 members had evidence of the MEA syndrome. Hyperparathyroidism was the most commonly recognized feature occurring in 10 of 13 affected members. Peptic ulcer occurred in 9 members and 5 died of complications secondary to ulcer perforation. Seven of the family were known to have one or more nonbeta islet cell adenomas, and 5 members were
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Frame B, Hartstock RJ, Ballard HS. Multiple Endocrine Adenomatosis.. Ann Intern Med. 1964;60:330. doi: 10.7326/0003-4819-60-2-330_1
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Published: Ann Intern Med. 1964;60(2_Part_1):330.
Endocrine and Metabolism, Endocrine Cancer, Hematology/Oncology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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