MARVIN A. SACKNER, M.D.; NECATI AKGUN, M.D.; PHILIP KIMBEL, M.D.; DAVID H. LEWIS, M.D.
SACKNER MA, AKGUN N, KIMBEL P, LEWIS DH. The Pathophysiology of Scleroderma Involving the Heart and Respiratory System. Ann Intern Med. 1964;60:611-630. doi: 10.7326/0003-4819-60-4-611
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Published: Ann Intern Med. 1964;60(4):611-630.
The lungs from patients with scleroderma show varying degrees of pulmonary fibrosis and medial hypertrophy of the pulmonary arterioles (1). However, little attention has been directed toward the hemodynamics of the pulmonary circulation particularly as related to the parenchymal alterations despite the morphologic observations consistent with pulmonary hypertension. Studies of pulmonary function show restrictive lung disease and impairment of gaseous diffusion, but tightness of the skin over the chest wall and myocardial fibrosis, which have been thought to produce physiologic disturbances, have not been critically evaluated (2-6). The purpose of the following report is to systematically investigate the physiologic nature
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Cardiology, Pulmonary/Critical Care, Rheumatology, Scleroderma.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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