Carlos E. Harrison, M.D.; Robert O. Brandenburg, M.D.; Patrick A. Ongley, M.D.; Alan L. Orvis, M.D.; Charles A. Owen, M.D.
Harrison CE, Brandenburg RO, Ongley PA, Orvis AL, Owen CA. A Compartmental Analysis of Single Intravenously Administered Doses of Tritiated Digoxin in Dogs.. Ann Intern Med. 1964;60:709. doi: 10.7326/0003-4819-60-4-709_1
Download citation file:
Published: Ann Intern Med. 1964;60(4):709.
This content is PDF only. Please click on the PDF icon to access.
Tritiated digoxin was injected into dogs to study degradation of the glycoside and rates of distribution and excretion. In four dogs with biliary fistula, an average of 72.5 per cent of an intravenous dose appeared in the urine (57.5 per cent) and bile (15.0 per cent) within 4.5 days; of this, 60 per cent was digoxin, and 40 per cent was in the form of a metabolite. These were differentially extracted from urine and in bile were distinguished chromatographically by use of a methyl isobutyl ketone : isopropyl ether : butanol system.
In two dogs with bile fistula, an average
Learn more about subscription options.
Register Now for a free account.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only