Abraham I. Braude, M.D.
Braude AI. Relationship Between Structure and Activity of Endotoxins.. Ann Intern Med. 1964;60:734. doi: 10.7326/0003-4819-60-4-734_1
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Published: Ann Intern Med. 1964;60(4):734.
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The pyrogens, or endotoxins, of gram-negative bacteria are large molecules (molecular weight approximately 200,000) containing three major components: lipids, proteins (or peptides), and polysaccharides. This pyrogenic complex can be extracted from the bacterial cell wall, where it acts as surface A antigen and permits serologic classification of enteric bacteria. The pyrogenic and other toxic properties of endotoxins are not an autonomous property of any one of the three components since toxicity is not appreciably affected by large variations in their relative amounts; instead the combined physicochemical properties of the entire molecule appear to be essential for the characteristic disturbances seen
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