D. Eugene Cowen, M.D. (Associate); David E. Dines, M.D., F.A.C.P.
Cowen DE, Dines DE. Cephalosporium Midline Granuloma.. Ann Intern Med. 1964;60:731-732. doi: 10.7326/0003-4819-60-4-731_3
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Published: Ann Intern Med. 1964;60(4):731-732.
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Herein is an original report of a 22-year-old white male Colorado farmer who developed a cephalosporium fungus infection. The fungus eroded through his hard palate, resulting in destructive changes in maxilla and mandible. Systemic manifestations of fever, weight loss, and hepatosplenomegaly were associated. Failure of response to surgical drainage, extraction of teeth, treatment with iodides and sulfa, necessitated intensive treatment with amphotericin B for 2 months, after which cultures for cephalosporium became negative.
Detailed allergic investigation to prevent a recurrence through the media of serial dilution techniques of intracutaneous testing, using endogenous airborne antigens disclosed a high degree of hypersensitivity
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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