Elisha Atkins, M.D.
Atkins E. Experimental Models in Studies in the Pathogenesis of Fever.. Ann Intern Med. 1964;60:732. doi: 10.7326/0003-4819-60-4-732_1
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Published: Ann Intern Med. 1964;60(4):732.
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Though fever has played a prominent role in the history of medicine, little has been learned until recently about its pathogenesis.
Various experimental models to investigate the cause of fever will be discussed. Most of these involve experimental infections or the intravenous injection of microbial materials into rabbits or dogs. In other instances, fevers of hypersensitivity have been induced by injection of antigen in specifically sensitized animals. On the basis of this work, it is postulated that most pyrogenic agents induce fever by releasing an intermediate circulating pyrogen from the tissues of the host. This pyrogen is believed to act
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