W. Barry Wood, M.D., F.A.C.P.
Wood WB. Factors Controlling the Release of Endogenous Pyrogen from Polymorphonuclear Leukocytes.. Ann Intern Med. 1964;60:732. doi: 10.7326/0003-4819-60-4-732_2
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Published: Ann Intern Med. 1964;60(4):732.
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The role of endogenous pyrogen in the pathogenesis of fever will have been discussed by the preceding speaker. That polymorphonuclear leukocytes constitute a major source of the endogenous pyrogen is clearly established. The mechanisms responsible for its release from leukocytes, on the other hand, are only partially understood.
Evidence will be presented that the release of pyrogen from granulocytes occurs in vivo: (a) when the cells engage in phagocytosis, (b) when they are exposed to appropriate concentrations of bacterial endotoxin, and (c) when they leave the blood stream and enter tissue exudate fluid, where they are acted upon by a
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