Paul J. Cannon, M.D.; John H. Laragh, M.D.
This content is PDF only. Please click on the PDF icon to access.
Ethacrynic acid has been found to be a most potent natriuretic and diuretic agent in man. The compound is an unsaturated ketone derivative of phenoxyacetic acid, chemically entirely different from previously known diuretic agents. The present study of over 50 patients suggests that its mode of action is also unique.
Oral dosages of 100 to 200 mg per day produced marked increases in sodium chloride and water excretion and clearing of edema fluid in refractory patients with congestive heart failure or with cirrhosis and ascites. It was often effective when all other measures had failed. Its diuretic effects were additive
Learn more about subscription options.
Register Now for a free account.
Cannon PJ, Laragh JH. Studies of Mechanism of Action and Effectiveness of Ethacrynic Acid, A New and Unique Diuretic Agent.. Ann Intern Med. 1964;60:738-739. doi: 10.7326/0003-4819-60-4-738_3
Download citation file:
Published: Ann Intern Med. 1964;60(4):738-739.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only