P. WILDING, B.SC., A.R.I.C.; W. T. COOKE, M.D., F.R.C.P.; G. I. NICHOLSON, M.R.A.C.P., M.R.C.P.
WILDING P, COOKE WT, NICHOLSON GI. Globulin-bound Amylase: A Cause of Persistently Elevated Levels in Serum. Ann Intern Med. 1964;60:1053-1059. doi: 10.7326/0003-4819-60-6-1053
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Published: Ann Intern Med. 1964;60(6):1053-1059.
Raised serum levels of amylase are associated with acute pancreatitis, mumps, certain acute abdominal conditions, and sometimes after the administration of opiates. According to Gray and Somogyi (1), persistently raised levels are to be found also in patients with impaired renal function, though Gross, Parker, Maher, and Power (2) found no significant increase in 63 patients with renal or extrarenal azotemia.
Several attempts have been made to determine whether amylase is associated with any specific protein in the serum. Cattaneo and Bassani (3) showed that amylase can be precipitated with the albumin fraction, using acetone at low temperature. With paper
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Celiac Disease and Malabsorption, Gastroenterology/Hepatology, Hospital Medicine, Pancreatic Disease.
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