WILLIAM H. SHAFER, M.D.
The association of severe peptic ulcer disease with a noninsulin-producing islet-cell carcinoma of the pancreas was described by Zollinger and Ellison (1) in 1955, and by 1960 more than 80 cases of this syndrome had been reported (2). It is now recognized that in this syndrome the initial symptom may be severe diarrhea, preceding peptic ulcer formation by many months or years (2-8). The case reported here is an example of a nonbeta islet-cell carcinoma initially presenting as a severe diarrhea.
A 16-year-old Negro boy was first examined at the Cleveland Clinic Hospital in January, 1961.
Learn more about subscription options.
Register Now for a free account.
SHAFER WH. Nonbeta Islet-cell Carcinoma of the Pancreas Presenting as Diarrhea: Report of a Case. Ann Intern Med. 1964;61:539–543. doi: 10.7326/0003-4819-61-3-539
Download citation file:
Published: Ann Intern Med. 1964;61(3):539-543.
Diarrhea, Gastroenterology/Hepatology, Hematology/Oncology, Pancreatic Disease.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only