WILLIS C. MADDREY, M.D.; FRANK L. IBER, M.D.
The familial occurrence of cirrhosis is unusual except in hepatolenticular degeneration, hemochromatosis, and a few other rare conditions. Eight families showing multiple patients with liver disease are presented, and the evidence suggesting a genetic predisposition is reviewed.
The criterion for acceptance into this study was histologically proved disease of the liver in two or more members of a sibship. All material was reviewed by the authors. Figure 1 indicates the time course of each patient.
Three of the ten children of W. E. (Figure 2) died of severe liver disease at early ages. A fourth died
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MADDREY WC, IBER FL. Familial Cirrhosis: A Clinical and Pathological Study. Ann Intern Med. 1964;61:667–679. doi: 10.7326/0003-4819-61-4-667
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Published: Ann Intern Med. 1964;61(4):667-679.
Gastroenterology/Hepatology, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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