Sidney Merlis, M.D., F.A.C.P.
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A large proportion of all chemical agents currently being submitted for clinical trial are those with potential psychopharmacological activity. Problems of evaluating comparative efficacy and toxicity in the absence of many specific physiological guide lines make conclusions tentative and suggestive, at best. The final arbiter for the successful application of a new drug for the treatment of psychiatric disease is the practicing clinician. This paper also discusses the problems of the researcher in handling the experimental drug trial and the difficulties facing the clinician in his use of psychopharmaceuticals.
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Merlis S. Problem of Evaluation of Psychopharmacological Drugs.. Ann Intern Med. 1964;61:802. doi: 10.7326/0003-4819-61-4-802_2
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Published: Ann Intern Med. 1964;61(4):802.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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