Edward G. Biglieri, M.D.; Paul E. Slaton, M.D.
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Hypertension associated with hypokalemia and increased aldosterone secretion is suggestive of primary aldosteronism. However, the combination of observations may occur in renal vascular or accelerated hypertension. Among 20 cases of proved primary aldosteronism, exceptions to each of the major clinical abnormalities have been seen. The chronic and excessive secretion of aldosterone in primary aldosteronism results in hypervolemia and hypernatremia, which are useful in distinguishing the hyperaldosteronism of adrenal from nonadrenal origin. In contrast, nonadrenal forms of hypertension may have reduced serum sodium concentration and blood volume.
The severe potassium depletion found in this disease also produces disturbances in carbohydrate metabolism,
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Biglieri EG, Slaton PE. The Recognition, Confirmation, and Course of Primary Aldosteronism.. Ann Intern Med. 1964;61:811. doi: 10.7326/0003-4819-61-4-811_2
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Published: Ann Intern Med. 1964;61(4):811.
Adrenal Disorders, Endocrine and Metabolism, Endocrine Cancer, Hematology/Oncology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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