Edward G. Biglieri, M.D.; Paul E. Slaton, M.D.
Biglieri EG, Slaton PE. The Recognition, Confirmation, and Course of Primary Aldosteronism.. Ann Intern Med. 1964;61:811. doi: 10.7326/0003-4819-61-4-811_2
Download citation file:
Published: Ann Intern Med. 1964;61(4):811.
This content is PDF only. Please click on the PDF icon to access.
Hypertension associated with hypokalemia and increased aldosterone secretion is suggestive of primary aldosteronism. However, the combination of observations may occur in renal vascular or accelerated hypertension. Among 20 cases of proved primary aldosteronism, exceptions to each of the major clinical abnormalities have been seen. The chronic and excessive secretion of aldosterone in primary aldosteronism results in hypervolemia and hypernatremia, which are useful in distinguishing the hyperaldosteronism of adrenal from nonadrenal origin. In contrast, nonadrenal forms of hypertension may have reduced serum sodium concentration and blood volume.
The severe potassium depletion found in this disease also produces disturbances in carbohydrate metabolism,
Learn more about subscription options.
Register Now for a free account.
Endocrine and Metabolism, Hematology/Oncology, Adrenal Disorders, Endocrine Cancer.
Results provided by:
Copyright © 2016 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only