Jack Brook, M.D., F.A.C.P.; Joseph R. Bateman, M.D. (Associate); Jesse L. Steinfeld, M.D., F.A.C.P.
Brook J, Bateman JR, Steinfeld JL. Recent Developments in the Treatment of Multiple Myeloma.. Ann Intern Med. 1964;61:813-814. doi: 10.7326/0003-4819-61-4-813_3
Download citation file:
Published: Ann Intern Med. 1964;61(4):813-814.
This content is PDF only. Please click on the PDF icon to access.
Until the recent introduction of phenylalanine mustard, the chemotherapy of multiple myeloma has been unsatisfactory. The use of agents such as urethane, stilbamidine derivatives, corticosteroids, radioactive phosphorus, mitomycin C, or combination of agents has not resulted in uniformly observed, objective responses in large numbers of patients. Although X-ray therapy and corticosteroids have been of some benefit, each of these agents alone has not been effective in producing either marked objective responses or increased survival.
Phenylalanine mustard, an oral alkylating agent, had been shown to have an anti-tumor effect, with the L-isomer (Melphalan, L-Sarcolysin) being most effective against animal and human
Learn more about subscription options.
Register Now for a free account.
Hematology/Oncology, Multiple Myeloma.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only