RICHARD J. COHEN; RICHARD C. SEVERANCE; EDWARD G. WHITING; GEORGE D. LUNDBERG
COHEN RJ, SEVERANCE RC, WHITING EG, LUNDBERG GD. A Study of the Juxtaglomerular Body in Primary Aldosteronism. Ann Intern Med. 1965;62:569-575. doi: 10.7326/0003-4819-62-3-569
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Published: Ann Intern Med. 1965;62(3):569-575.
It has been postulated recently that an interdependent system involving renin, angiotensin, and aldosterone may be involved in the production of certain types of human hypertension (1, 2). A number of studies have demonstrated an interaction of renin with angiotensin I to form angiotensin II (3-5), which stimulates aldosterone secretion by the zona glomerulosa of the adrenal cortex (3, 6-8). Aldosterone, by means of its potent mineralocorticoid effect on sodium and potassium balance, produces an elevation in systemic arterial blood pressure (2-9). The use of microdissection (10-13) and fluorescent antibody techniques (14) has localized renin production to the juxtaglomerular body
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Adrenal Disorders, Endocrine and Metabolism, Endocrine Cancer, Hematology/Oncology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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