Panoyotis Katsoyannis, Ph.D.
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The synthesis of the A- and B-chains of insulin and their isolation in the S-sulfonate form were accomplished. Combination experiments between the synthetic A- and natural B-chain, the synthetic B- and the natural A-chain, and between the synthetic A- and B-chains generated insulin activity. The yield of the generated activity in all cases was within the range of the activity obtained when similarly treated natural A- and B-chains are combined. This work represents the first chemical synthesis of a naturally occurring protein and constitutes a case in which the proposed primary structure of a protein has been confirmed by chemical
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Katsoyannis P. Total Synthesis of Insulin.. Ann Intern Med. 1965;62:1079. doi: 10.7326/0003-4819-62-5-1079_2
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Published: Ann Intern Med. 1965;62(5):1079.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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