John H. Bland, M.D., F.A.C.P.; Richard L. Lipson, M.D. (Associate); Fred W. Dunihue, M.D.; Bert K. Kusserow, M.D.; Jackson J. W. Clemmons, M.D.; Leah E. Williams
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Though the Ehler's-Danlos syndrome has a more ancient history than the other genetic disorders of connective tissue, the basic abnormality at a molecular level remains controversial. The present study is a combined biochemical, histological, and chromosomal investigation in four members of a family with Ehler's-Danlos syndrome, a mother and three siblings. They were placed on collagen-free diets for periods of 23 days in 3 patients and 52 days in one patient and the following urinary excretion rates determined daily: hydroxyproline, hexosamine, uronic acid, total nitrogen, creatinine, and uric acid. Daily osmolality measurements were made. Both hydroxyproline and uronic acid excretion
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Bland JH, Lipson RL, Dunihue FW, Kusserow BK, Clemmons JJW, Williams LE. A Biochemical, Histological (Light and Electron Microscopy), and Chromosomal Study of a Family with Ehler's-Danlos Syndrome.. Ann Intern Med. 1965;62:1087. doi: 10.7326/0003-4819-62-5-1087_2
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Published: Ann Intern Med. 1965;62(5):1087.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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