LEON D. OSTRANDER, M.D., F.A.C.P.; THOMAS FRANCIS, M.D., SC.D.; NORMAN S. HAYNER, M.D.; MARCUS O. KJELSBERG, PH.D.; FREDERICK H. EPSTEIN, M.D.
The high prevalence of vascular disease among diabetics has long been recognized and has become increasingly important since the acute complications of diabetes, acidosis, and infection have been controlled. With a longer life span cardiovascular disease is now the major complication of diabetes. Only 17% of diabetics died of vascular disease in 1914, but by 1957 it was the cause of death in 77% of the patients in one large series (1). Besides the well-known capillary lesions, the vascular complications have included coronary and peripheral atherosclerotic occlusive disease, hypertension, and cerebrovascular disease.
The higher prevalence and greater severity of coronary
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OSTRANDER LD, FRANCIS T, HAYNER NS, KJELSBERG MO, EPSTEIN FH. The Relationship of Cardiovascular Disease to Hyperglycemia. Ann Intern Med. 1965;62:1188-1198. doi: 10.7326/0003-4819-62-6-1188
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Published: Ann Intern Med. 1965;62(6):1188-1198.
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