WARREN E. GOORNO, M.D.; NORMAN M. KAPLAN, M.D., F.A.C.P.
The kidney may cause hypertension by the elaboration of a pressor material in the presence of renal ischemia. The prevailing theory is that a decrease in the pressure within the renal afferent arteriole (1, 2) causes the juxtaglomerular apparatus to release the enzyme renin (3), which in turn acts enzymatically upon a substrate in the circulation to produce the decapeptide angiotensin I. Angiotensin I is then acted upon by a converting enzyme to produce the potent pressor octapeptide, angiotensin II (4).
We have attempted to assess the role of the renal pressor mechanism in various hypertensive states. Two different methods
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GOORNO WE, KAPLAN NM. Renal Pressor Material in Various Hypertensive Diseases. Ann Intern Med. 1965;63:745–751. doi: 10.7326/0003-4819-63-5-745
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Published: Ann Intern Med. 1965;63(5):745-751.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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