Jay N. Cohn, M.D.; Myron H. Luria, M.D.
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Clinical hypotension and shock in the absence of blood loss often is characterized by low or normal right atrial pressure and low cardiac output. A rapid infusion of 500 ml dextran in 19 patients with this hemodynamic pattern resulted in marked clinical and circulatory improvement. Arterial pressure rose from an average of 80/45 to 113/59 mm Hg; cardiac output increased from an average of 3.1 to 5.8 liters/min; and peripheral vascular resistance fell from a mean of 1,637 to 1,035 dynes sec/cm5. The signs and symptoms of shock were reversed in many of the patients. Clinical diagnoses in these patients
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Cohn JN, Luria MH. Hemodynamic and Clinical Effects of Dextran in Nonhemorrhagic Shock in Man.. Ann Intern Med. 1965;63:904. doi: 10.7326/0003-4819-63-5-904_2
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Published: Ann Intern Med. 1965;63(5):904.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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