John W. Yarbro, M.D. (Associate); Paul Engstrom, M.D.; B. J. Kennedy, M.D., F.A.C.P.
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Hydroxyurea is effective against a variety of neoplasms. During the administration of this agent, bone marrow suppression occurred as manifested by a decrease in reticulocytes, leukopenia, thrombocytopenia, and anemia. Most significantly, a marked megaloblastosis was observed during and immediately after the administration of hydroxyurea. Because of the relationship between megaloblastosis and nucleic acid metabolism, an investigation of this phenomena was undertaken by a study of the effect of hydroxyurea on nucleic acid metabolism in a transplantable ascites tumor in C3M mice. Nucleic acid synthesis was determined by means of incorporation of P32 orthophosphate into deoxyribonucleic acid (DNA) and ribonucleic acid
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Yarbro JW, Engstrom P, Kennedy BJ. DNA Inhibition as an Explanation of Hydroxyurea Induced Megaloblastosis.. Ann Intern Med. 1965;63:917. doi: 10.7326/0003-4819-63-5-917_1
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Published: Ann Intern Med. 1965;63(5):917.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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