DOROTHY L. WILLIAMS, M.D.; JOHN W. RUNYAN, M.D., F.A.C.P.
During the past several years there has been much improvement and simplification of cytogenetic techniques. This has helped to remove this field from the realm of basic research and investigation to that of increasing practical importance to clinical medicine. It can now be a valuable aid in the understanding, diagnosis, and sometimes the treatment of abnormalities and syndromes previously poorly understood. Cytogenetics attempts to correlate the microscopic structural and numerical abnormalities of chromosomes with the clinical changes and syndromes associated with them.
Since population surveys are now available concerning the known frequencies of specific syndromes, these data at once add
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WILLIAMS DL, RUNYAN JW. Sex Chromatin and Chromosome Analysis in the Diagnosis of Sex Abnormalities. Ann Intern Med. 1966;64:422–459. doi: 10.7326/0003-4819-64-2-422
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Published: Ann Intern Med. 1966;64(2):422-459.
Endocrine and Metabolism, Hematology/Oncology, Neurology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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