DONALD A. ADAMS, M.D.; ERNEST M. GOLD, M.D.; HARVEY C. GONICK, M.D., F.A.C.P.; MORTON H. MAXWELL, M.D., F.A.C.P.
Corticosteroid therapy regularly suppresses adrenocortical function although upon withdrawal of exogenous steroids restoration of adrenal function is said to occur within several days (1, 2). However, recent evidence indicates that suppression commonly may persist for as long as 6 to 9 months (3). The clinical consequences of this problem are difficult to document other than as isolated reports relating prior steroid treatment to hypotension or sudden death associated with minor trauma or surgical procedures (4-6). The problem of adrenocortical suppression assumes increasing importance now that widespread clinical usage of corticosteroids is approaching 15 treatment years.
Evaluation of intermittent steroid treatment
Learn more about subscription options.
Register Now for a free account.
ADAMS DA, GOLD EM, GONICK HC, MAXWELL MH. Adrenocortical Function During Intermittent Corticosteroid Therapy. Ann Intern Med. 1966;64:542–551. doi: 10.7326/0003-4819-64-3-542
Download citation file:
Published: Ann Intern Med. 1966;64(3):542-551.
Adrenal Disorders, Autoimmune Kidney Disease, Endocrine and Metabolism, Lupus Erythematosus, Nephrology.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only