DONALD A. ADAMS, M.D.; ERNEST M. GOLD, M.D.; HARVEY C. GONICK, M.D., F.A.C.P.; MORTON H. MAXWELL, M.D., F.A.C.P.
ADAMS DA, GOLD EM, GONICK HC, MAXWELL MH. Adrenocortical Function During Intermittent Corticosteroid Therapy. Ann Intern Med. 1966;64:542-551. doi: 10.7326/0003-4819-64-3-542
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Published: Ann Intern Med. 1966;64(3):542-551.
Corticosteroid therapy regularly suppresses adrenocortical function although upon withdrawal of exogenous steroids restoration of adrenal function is said to occur within several days (1, 2). However, recent evidence indicates that suppression commonly may persist for as long as 6 to 9 months (3). The clinical consequences of this problem are difficult to document other than as isolated reports relating prior steroid treatment to hypotension or sudden death associated with minor trauma or surgical procedures (4-6). The problem of adrenocortical suppression assumes increasing importance now that widespread clinical usage of corticosteroids is approaching 15 treatment years.
Evaluation of intermittent steroid treatment
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Endocrine and Metabolism, Nephrology, Rheumatology, Nephrotic Syndrome, Adrenal Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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