WILLIAM BELL, M.D.; RAYMOND BAHR, M.D.; THOMAS A. WALDMANN, M.D.; PAUL P. CARBONE, M.D.
In 1955, Korst and Kratochvil (1) reported a patient with a pulmonary neoplasm and thrombophlebitis migrans in whom a cold-preciptable fibrinogen (cryofibrinogen) was detected. Subsequently, cryofibrinogenemia has been described as a primary (idiopathic) and more frequently as a secondary disorder (2). Primary (2) and secondary (3) cryofibrinogenemia may be associated with cold intolerance, Raynaud's phenomenon, and acrocyanosis. In the secondary disorder, thrombo-embolic occlusive phenomena and hemorrhagic diatheses are common.
The present report concerns a patient with a primary hepatoma and markedly elevated plasma levels of fibrinogen and cryofibrinogen. These findings were not associated with any thrombotic or bleeding disorders or
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BELL W, BAHR R, WALDMANN TA, CARBONE PP. Cryofibrinogenemia, Multiple Dysproteinemias, and Hypervolemia in a Patient with a Primary Hepatoma. Ann Intern Med. 1966;64:658–664. doi: 10.7326/0003-4819-64-3-658
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Published: Ann Intern Med. 1966;64(3):658-664.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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