WILLIAM CARTER, M.D.; KENNETH S. MCCARTY, PH.D.
II. Review of the molecular mechanisms of replication, information transfer, and protein synthesis
III. Antibiotics which modify the molecular mechanisms of replication, information transfer, and protein synthesis
A. Assembly of nucleotide substrates Psicofuranine
B. Replication of genetic information Mitomycins, Porfiromycin, Nalidixic Acid and Griseofulvin
C. Transcription of genetic information Actinomycin D
D. Translation of genetic information
1. Amino acid activation
2. The ribosome
a. mRNA binding Chloramphenicol
b. tRNA binding Tetracyclines
c. mRNA translation Streptomycin, Kanamycin and Neomycin
3. Peptide synthesis Puromycin
4. Locus Unclear Erythromycin, Lincomycin
IV. Antibiotics that influence the function or biosynthesis of the
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CARTER W, MCCARTY KS. Molecular Mechanisms of Antibiotic Action. Ann Intern Med. 1966;64:1087–1113. doi: 10.7326/0003-4819-64-5-1087
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Published: Ann Intern Med. 1966;64(5):1087-1113.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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