Leo L. Stolbach, M.D.; Melvin J. Krant, M.D.; Susan C. Sebestyen, M.D.; Norma I. Inglis, A.B.; William H. Fishman, Ph.D.
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A number of isoenzymes of alkaline phosphatase have been found in human serum, and it has been assumed that liver and bone are the main tissue sources of these enzymes. A serum alkaline phosphatase of intestinal origin has now been identified by (1) its characteristic inhibition of enzyme activity in the presence of L-phenylalanine and (2) its location as a band of activity, after starch gel electrophoresis, migrating to the position for purified intestinal alkaline phosphatase. A similar band (unidentified as to organ source) has been related to the ABO blood types of normal individuals by other workers.
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Stolbach LL, Krant MJ, Sebestyen SC, Inglis NI, Fishman WH. Correlation of Serum Alkaline Phosphatase of Intestinal Origin with the ABO Blood Group of Cirrhotics.. Ann Intern Med. 1966;64:1161–1162. doi: 10.7326/0003-4819-64-5-1161_3
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Published: Ann Intern Med. 1966;64(5):1161-1162.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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