James W. Davis, M.D. (Associate); Sloan J. Wilson, M.D., F.A.C.P.
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The May-Hegglin anomaly has been established as an inherited clinical entity on the basis of 28 patients reported by eight authors. It is characterized by mild hemorrhagic manifestations accompanied by the finding of giant platelets and inclusions (Döhle bodies) in the cytoplasm of leukocytes. Platelet values have been reported in only 15 subjects, 12 being thrombocytopenic. We have observed 14 subjects with the anomaly, and believe the additional data may lead to a clearer concept of the disease.
The clinical and laboratory data are of interest. Hemorrhagic tendencies are mild. In one of our families, the following operations and injuries
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Davis JW, Wilson SJ. The May-Hegglin Anomaly: An Inherited Thrombocytic and Neutrophilic Defect.. Ann Intern Med. 1966;64:1164–1165. doi: 10.7326/0003-4819-64-5-1164_3
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Published: Ann Intern Med. 1966;64(5):1164-1165.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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