William H. Knospe
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The only consistent cytogenetic abnormality heretofore described among the human leukemias has been the Ph′ chromosome of chronic granulocytic leukemia. Several previous reports have described hyperdiploid cell lines with two Ph1 chromosomes.
Case 1, a 25-year-old man, developed chronic granulocytic leukemia after a 5-month illness. He responded poorly to busulfan, and his course was complicated by massive painful lymphadenopathy and blast crisis. A lymph node biopsy section was initially interpreted as reticulum cell sarcoma but later revised to infiltration by primitive granulocytes. The granulocytes had a clonal line of 52 chromosomes including two Ph′ chromosomes. Lymphocytes from blood and lymph
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Knospe WH. Unusual Cytogenetic Changes in Chronic Granulocytic Leukemia in Blast Crisis: Hyperdiploid and Two Ph′ Chromosomes.. Ann Intern Med. 1966;64:1165. doi: 10.7326/0003-4819-64-5-1165_2
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Published: Ann Intern Med. 1966;64(5):1165.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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