William McK. Jefferies, M.D., F.A.C.P.
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Therapeutic effectiveness of glucocorticoids in clinical disorders has been thought to depend upon production of a state of hypercorticism with its accompanying hazards. As experience has accumulated, it has become apparent that doses of cortisone acetate too small to produce hypercorticism may have clinically beneficial effects in arthritic and allergic diseases as well as in some cases of ovarian dysfunction, hirsutism, acne, and chronic cystic mastitis.
In studies of the effects of low-dosage glucocorticoid therapy in over 200 patients with various disorders for periods up to 8 years, it has been found that (1) these doses can significantly affect steroid
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Jefferies WM. Low-Dosage Glucocorticoid Therapy.. Ann Intern Med. 1966;64:1184. doi: 10.7326/0003-4819-64-5-1184_4
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Published: Ann Intern Med. 1966;64(5):1184.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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