JEAN DE GROUCHY, M.D.
The first observations by German (1) and German, Archibald, and Bloom (2) on Bloom's syndrome and by Schroeder, Anschütz, and Knopp (3) on Fanconi's anemia suggested that two diseases, probably under simple genetic control, may induce an abnormal frequency of chromosome rearrangements in the somatic cells of affected individuals. Taken together with the strikingly increased prevalence of malignancy in the same patients, these observations prove highly significant in the general problem of the relation between chromosomal aberrations and malignancy.
This issue of the ANNALS presents two outstanding contributions to this subject. One paper, by Swift and Hirschhorn, reports on two
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DE GROUCHY J. Genetic Diseases, Chromosome Rearrangements, and Malignancy. Ann Intern Med. 1966;65:603–607. doi: 10.7326/0003-4819-65-3-603
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Published: Ann Intern Med. 1966;65(3):603-607.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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