JOSEPH GAFNI, M.D.; HANS-JOACHIM MERKER, M.D.; SHLOMO SHIBOLET, M.D.; EZRA SOHAR, M.D.; HARRY HELLER, M.D.
GAFNI J, MERKER H, SHIBOLET S, SOHAR E, HELLER H. On the Origin of Amyloid: Study of an Amyloid Tumor in Multiple Myeloma. Ann Intern Med. 1966;65:1031-1044. doi: 10.7326/0003-4819-65-5-1031
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Published: Ann Intern Med. 1966;65(5):1031-1044.
Almost since the discovery of amyloid there has been much speculation as to the mode and site of its formation. Its common association with protracted inflammatory diseases and multiple myeloma implicated the production, presumably by plasma cells, of a soluble abnormal protein that was carried by the circulation to the site of its precipitation by immune mechanisms in the connective tissue ground substance (1-4). The finding of plasma cell infiltrates in meticulously re-examined cases of "primary" amyloidosis added weight to this theory (5, 6). In recent years, however, the local deposition of such a distantly produced precursor has been denied
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Hematology/Oncology, Multiple Myeloma.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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