PHILIP M. GRIMLEY, M.D.
GRIMLEY PM. Rheumatoid Arthritis: Ultrastructure of the Synovium. Ann Intern Med. 1967;66:623-624. doi: 10.7326/0003-4819-66-3-623
Download citation file:
Published: Ann Intern Med. 1967;66(3):623-624.
Several lines of investigation have recently focused attention on the ultrastructure of the synovium in rheumatoid arthritis. Electron microscopy has shown that a significant proportion of the synovial lining cells correspond to macrophages in both cytologic organization and phagocytic potential (1, 2). These cells, sometimes designated type A or type M, undergo a pronounced hyperplasia in rheumatoid arthritis and display intense acid phosphatase activity. Multinucleated giant cells of macrophage (type A cell) origin also occur with some frequency (3) and contain similar hydrolytic enzyme.
Current thinking about the nature of rheumatoid arthritis is dominated by a concern with hypersensitivity mechanisms,
Learn more about subscription options.
Register Now for a free account.
Rheumatoid Arthritis, Rheumatology.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use
This PDF is available to Subscribers Only