PHILIP M. GRIMLEY, M.D.
Several lines of investigation have recently focused attention on the ultrastructure of the synovium in rheumatoid arthritis. Electron microscopy has shown that a significant proportion of the synovial lining cells correspond to macrophages in both cytologic organization and phagocytic potential (1, 2). These cells, sometimes designated type A or type M, undergo a pronounced hyperplasia in rheumatoid arthritis and display intense acid phosphatase activity. Multinucleated giant cells of macrophage (type A cell) origin also occur with some frequency (3) and contain similar hydrolytic enzyme.
Current thinking about the nature of rheumatoid arthritis is dominated by a concern with hypersensitivity mechanisms,
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GRIMLEY PM. Rheumatoid Arthritis: Ultrastructure of the Synovium. Ann Intern Med. 1967;66:623–624. doi: 10.7326/0003-4819-66-3-623
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Published: Ann Intern Med. 1967;66(3):623-624.
Rheumatoid Arthritis, Rheumatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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