Avery A. Sandberg, M.D.
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Human neoplasia is a heterogenous group of diseases, and hence it is not unexpected that the karyotypic findings in cancer and leukemia are protein in nature. The chromosomal constitutions in these conditions range from diploidy, impressive hypodiploidy, to high hyperploidy. Except for chronic myelocytic leukemia, no consistent karyotypic picture has emerged for any group of cancer or leukemia. As a matter of fact, no two similar karyotypes have been found in human cancer (primary and metastatic). These findings coupled with the high frequency of diploidy in acute leukemia indicate that gross genomic aberrations cannot be imputed as being involved in
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Sandberg AA. Chromosome Abnormalities in Human Neoplastic Disease and Their Implications.. Ann Intern Med. 1967;66:1044. doi: 10.7326/0003-4819-66-5-1044_1
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Published: Ann Intern Med. 1967;66(5):1044.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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