James P. Smith, M.D.; Richard W. Stone, M.D.; Carl Muschenheim, M.D., F.A.C.P.
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Mortality from acute respiratory failure in patients with chronic obstructive lung disease remains high (18 to 70%) in reported series. The possibility that the discouraging results of treatment are related in part to the widely recommended use of mechanical respirators has prompted an evaluation of a more conservative approach to therapy in patients with severe failure (Paco2, 55 mm Hg or more; arterial pH, 7.35 or less; and arterial oxygen saturation (SaO2), 85% or lower).
Precisely controlled oxygen, delivered according to the principle of high airflow with oxygen enrichment (Ventimask), and intensive supportive measures are used as initial therapy for
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Smith JP, Stone RW, Muschenheim C. Management of Acute Respiratory Failure in Bronchitis and Emphysema with Observations on Controlled Oxygen Therapy.. Ann Intern Med. 1967;66:1056–1057. doi: 10.7326/0003-4819-66-5-1056_3
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Published: Ann Intern Med. 1967;66(5):1056-1057.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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