Herbert Gershberg, M.D., F.A.C.P.; Zenaida C. Javier, M.D.; Mildred M. Hulse, M.S.
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Approximately 45% of women taking oral contraceptives over 3 years have impaired glucose tolerance, and 85% have abnormal cortisone glucose tolerance. Five milligrams norethynodrel and 0.075 mg mestranol, 1 mg ethynodiol diacetate and 0.10 mg mestranol, and (sequential) 0.080 mg mestranol for 15 days and 0.080 mg mestranol and 2 mg chlormadinone acetate for 5 days—all produce these changes. The responsible component is the estrogen, and administration of 0.075 mg mestranol daily produces similar changes.
A reduction in insulin secretion is not the cause of the abnormalities since insulin secretion in response to glucose initially increases. The serum insulin binding
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Gershberg H, Javier ZC, Hulse MM. Oral Contraceptives, Estrogen, and Carbohydrate Metabolism.. Ann Intern Med. 1967;66:1059. doi: 10.7326/0003-4819-66-5-1059_1
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Published: Ann Intern Med. 1967;66(5):1059.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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