Thomas C. Hall, M.D., F.A.C.P.; D. Roberts; D. Kessell
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Effective antileukemic agents are available for most forms of adult leukemia. Response frequency is low and time to remission, long. Progression of disease to death occurs in many patients before sequential therapeutic trials in search of an effective agent can be completed. Drug transport into cells, metabolism to active or inactive forms, the presence of target enzymes, and net effects on nucleic acid synthesis in the malignant cell may all be involved in the induction of a clinical remission. Isotopic micromethods have been developed in this laboratory for the measurement of the target enzymes for methotrexate (MTX) and 5-fluorouracil (FU),
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Hall TC, Roberts D, Kessell D. Early Prediction of Clinical Responses to Anticancer Drugs.. Ann Intern Med. 1967;66:1064. doi: 10.7326/0003-4819-66-5-1064_2
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Published: Ann Intern Med. 1967;66(5):1064.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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